Scientific Meeting Highlights from SITC

ASCO 2024 Annual Meeting (June 4)

By Thomas Martin posted 06-05-2024
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the ASCO 2024 Annual Meeting. Below is a recap of highlighted research presented from Tuesday, June 4, 2024. 2024 Scientific Highlights Safety and efficacy of immune checkpoint inhibitor atezolizumab in patients with advanced solid tumors with high tumor mutation burden LBA2509. Atezolizumab in patients (pts) with tumor mutational burden (TMB)–high tumors from the TAPISTRY trial. Rafal Dziadziuszko (Department of Oncology & Radiotherapy and Early Phase Clinical Trials Centre, Medical ...
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ASCO 2024 Annual Meeting (June 3)

By Thomas Martin posted 06-04-2024
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the ASCO 2024 Annual Meeting. Below is a recap of highlighted research presented from Monday, June 3, 2024. 2024 Scientific Highlights Combination therapy with lenvatinib and pembrolizumab is associated with clinical benefits for advanced renal cell carcinoma across a variety of biomarker subtypes 4504. Biomarker analyses in patients with advanced renal cell carcinoma (aRCC) from the phase 3 CLEAR trial. Toni K. Choueiri (Dana Farber Cancer Institute, Boston, MA) reported biomarker analyses ...
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ASCO 2024 Annual Meeting (June 2)

By Thomas Martin posted 06-03-2024
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the ASCO 2024 Annual Meeting. Below is a recap of highlighted research presented from Sunday, June 2, 2024. 2024 Scientific Highlights Blockade of TIGIT improves the anti-tumor efficacy of pembrolizumab for previously treated advanced mismatch repair-deficient endometrial cancer 5502. Vibostolimab coformulated with pembrolizumab (vibo/pembro) for previously treated advanced mismatch repair–deficient (dMMR) endometrial cancer: Results from cohort B1 of the phase 2 KEYVIBE-005 study. Carlos ...
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ASCO 2024 Annual Meeting (June 1)

By Thomas Martin posted 06-02-2024
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the ASCO 2024 Annual Meeting. Below is a recap of highlighted research presented from Saturday, June 1, 2024. 2024 Scientific Highlights Safety and efficacy of a cell-based immunotherapeutic vaccine combined with durvalumab for second-line treatment of HPV 16- or 18-positive cervical cancer 5513. An open label, single arm phase II, multicenter trial of durvalumab and BVAC-C, in patients with HPV 16- or 18-positive cervical cancer and failure of first-line platinum-based chemotherapy (DURBAC). ...
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ASCO 2024 Annual Meeting (May 31)

By Thomas Martin posted 06-01-2024
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the ASCO 2024 Annual Meeting. Below is a recap of highlighted research presented from Friday, May 31, 2024. 2024 Scientific Highlights Phase I study of immune checkpoint inhibition for advanced secondary angiosarcomas 11513. Cemiplimab in locally advanced and/or metastatic secondary angiosarcomas (CEMangio): A phase II clinical trial. Stefan van Ravensteijn (Radboud UMC, Nijmegen, Gelderland, Netherlands) presented a single-arm multicenter phase II clinical trial investigating the ...
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AACR Annual Meeting 2024

By Thomas Martin posted 04-11-2024
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the 2024 AACR Annual Meeting. Below is a recap of highlighted research presented from Friday, April 5–Wednesday, April 10, 2024. 2024 Scientific Highlights Long-term follow-up of CD70-targeting allogeneic CAR T cell therapy for refractory clear cell renal cell carcinoma CT002. CTX130 allogeneic CRISPR-Cas9-engineered chimeric antigen receptor (CAR) T cells in patients with advanced clear cell renal cell carcinoma: Long-term follow-up and translational data from the phase 1 COBALT-RCC study ...
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March 15, 2024: Meeting of the Oncologic Drugs Advisory Committee

By Thomas Martin posted 03-19-2024
The Society for Immunotherapy of Cancer (SITC) is pleased to present a summary of the U.S. Food & Drug Administration (FDA) Meeting of the Oncologic Drugs Advisory Committee (ODAC) . Below is a recap of highlighted research presented from Friday, March 15, 2024. Morning session: Supplemental biologics license application (sBLA) 125746.7 for ciltacabtagene autoleucel Ciltacabtagene autoleucel (cilta-cel, CARVYKTI), a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell therapy initially obtained approval for adult patients with relapsed or refractory multiple myeloma (r/r MM) after four ...
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ASH Annual Meeting 2023

By SITC Communications posted 12-13-2023
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the 2023 ASH Annual Meeting. Below is a recap of highlighted research presented from Saturday, Dec. 9–Tuesday, Dec. 12, 2023 2023 Scientific Highlights Real-world safety and efficacy study of the BCMAxCD3 bispecific antibody teclistamab for relapsed or refractory multiple myeloma 91. Real-world safety and efficacy of teclistamab for patients with heavily pretreated relapsed-refractory multiple myeloma Danai Dima (Cleveland Clinic, Cleveland, OH, USA) ...
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ESMO IO Congress 2023

By SITC Communications posted 12-11-2023
2023 Scientific Highlights The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the 2023 ESMO Iummuno-Oncology Congress. Below is a recap of highlighted research presented from Wednesday, Dec. 6–Friday, Dec. 8, 2023 Results from GDFATHER-1/2, the first in-human trial of visugromab, a GDF-15 neutralizing antibody 118O. Definitive results for NSCLC and bladder cancer cohorts in the phase 2a trial of visugromab (CTL-002) in advanced/metastatic anti-PD/PD-L1 relapsed/refractory solid tumors (GDFATHER-trial) Ignacio ...
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SITC 2023 SCIENCE COVERAGE (NOV. 5)

By SITC Communications posted 11-05-2023
Use of vaccines to boost CAR T efficacy and promote antigen spreading for long-term anti-tumor activity 286. Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity Leyuan Ma (Children’s Hospital of Philadelphia, Philadelphia, PA, USA) reported results from a study of a synthetic vaccine (amph-vax) to enhance CAR T cell activity against solid tumors. Amph-vax consisted of a CAR-ligand linked to albumin-binding poly (ethylene glycol)-phospholipid and formulated with a cyclic-di-GMP (STING agonist). Fluorescently labeled amph-vax targeted lymph nodes and associated with antigen presenting cells ...
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SITC 2023 SCIENCE COVERAGE (NOV. 4)

By SITC Communications posted 11-04-2023
Correlation of tertiary lymphoid structures with survival benefits in patients treated with first line atezolizumab for metastatic lung cancer 606. IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab Barzin Nabet (Genentech, South San Francisco, CA, USA) presented an analysis to evaluate the clinical utility of tertiary lymphoid structures (TLS) as a biomarker associated with clinical benefits from immunotherapy in patients with untreated metastatic non-small cell lung cancer (mNSCLC). Prior studies have indicated that B-cell and plasma-cell ...
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SITC 2023 Science Coverage (Nov. 3)

By SITC Communications posted 11-03-2023
Neutrophils are important for the destruction of heterogenous tumors in mouse models of melanoma 878. T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants Daniel Hirschhorn (Weill Cornell Medical and Graduate Schools, New York, NY, USA) presented a study investigating the mechanisms of immune-mediated destruction of heterogeneous tumors that contain antigen-loss variants. Selective pressures of the immune system create heterogeneity and antigen-loss variants within tumors, and this heterogeneity often leads to resistance to T cell-targeted immunotherapies. Mouse models of Trp1+ B16 melanoma ...
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ESMO Congress 2023

By SITC Communications posted 10-25-2023
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the 2023 ESMO Congress. Below is a recap of highlighted research presented from Friday, October 20 through Tuesday, October 24, 2023. Exploring the clinical effectiveness of perioperative immune checkpoint inhibitors in combination with chemotherapy for advanced gastric and gastroesophageal junction cancer LBA74. Pembrolizumab plus chemotherapy vs chemotherapy as neoadjuvant and adjuvant therapy in locally advanced gastric and gastroesophageal junction cancer: The phase III KEYNOTE-585 study Kohei Shitara ...
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ASCO ANNUAL MEETING 2023 (JUNE 6)

By SITC Communications posted 06-06-2023
Lisocabtagene maraleucel for relapsed or refractory chronic lymphocytic leukemia and small lymphocytic leukemia 7501. Lisocabtagene maraleucel (liso-cel) in R/R chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Primary analysis of TRANSCEND CLL 004. Tanya Siddiqi (City of Hope National Medical Center, Duarte, CA) presented efficacy and safety data from the primary efficacy analysis set (n=87) of TRANSCEND CLL 004, which examined lisocabtagene maraleucel (liso-cel), a CD19-directed CAR T cell product in relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The Primary ...
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ASCO ANNUAL MEETING 2023 (JUNE 5)

By SITC Communications posted 06-05-2023
Nivolumab-based neoadjuvant chemoimmunotherapy followed by response-adapted chemoradiation therapy is associated with deep responses and favorable survival for HNSCC 6007. Neoadjuvant nivolumab, paclitaxel, and carboplatin followed by response-stratified chemoradiation in locoregionally advanced HPV negative head and neck squamous cell carcinoma (HNSCC): The DEPEND trial. Ari Rosenberg (University of Chicago, Chicago, IL – SITC Member ) reported results from the phase II DEPEND trial of neoadjuvant chemoimmunotherapy followed by chemoradiation therapy (CRT) for advanced HPV-negative head and neck squamous cell carcinoma (HNSCC). ...
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ASCO ANNUAL MEETING 2023 (JUNE 4)

By SITC Communications posted 06-04-2023
Blockade of immune modulator GDF-15 combined with nivolumab for advanced solid tumors 2501. Initial results from the phase 2A trial of visugromab (CTL-002) + nivolumab in advanced/metastatic anti-PD1/-L1 relapsed/refractory solid tumors (The GDFATHER-TRIAL). Ignacio Melero Bermejo (Clinica Universitaria de Navarra, Pamplona, Spain) reported initial results from the GDFATHER-TRIAL, a phase IIa trial of visugromab (CTL-002) combined with nivolumab for advanced or metastatic solid tumors. CTL0-002 blocks GDF-15, an immune modulating molecule that inhibits the infiltration of immune cells into the tumor microenvironment and limits the efficacy ...
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ASCO ANNUAL MEETING 2023 (JUNE 3)

By SITC Communications posted 06-03-2023
Perioperative pembrolizumab is associated with survival benefits for early-stage NSCLC LBA100. KEYNOTE-671: Randomized, double-blind, phase 3 study of pembrolizumab or placebo plus platinum-based chemotherapy followed by resection and pembrolizumab or placebo for early stage NSCLC. Heather A. Wakelee (Stanford University, Stanford, CA) presented an interim analysis of KEYNOTE-671, a randomized, double-blind phase III trial investigating a perioperative approach that includes immune checkpoint inhibition before and after surgical resection of stage II, IIIA or IIIB(N2) non-small cell lung cancer (NSCLC) per AJCC v8. Patients were ...
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ASCO Annual Meeting 2023 (June 2)

By SITC Communications posted 06-02-2023
Dual-target natural killer cell engager for treatment of acute myeloid leukemia 7005. A first-in-human study of CD123 NK cell engager SAR443579 in relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, or high-risk myelodysplasia . Anthony Selwyn Stein (City of Hope National Medical Center, Duarte, CA) presented preliminary safety and efficacy data from phase I/II trial of SAR443579 (SAR’579), a trifunctional natural killer (NK) cell engager for relapsed or refractory (r/r) acute myeloid leukemia (AML). SAR’579 targets CD123, which is widely expressed in hematologic malignancies, and co-engages NKp46 and Cd16a ...
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ASGCT Annual Meeting 2023

By SITC Communications posted 05-23-2023
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the 2023 ASGCT Annual Meeting. Below is a recap of highlighted research presented from Tuesday, May 16 through Saturday, May 20, 2023. Scientific Highlights CAR signaling domains affect the dynamics of CAR T cell anti-cancer activity 89: CAR Signaling Drives Distinct Immunological Synapse Dynamics That Influence the T Cell Behavior in Killing Cancer Ahmed Z. Gad (Baylor College of Medicine, Houston, TX) presented a study comparing the dynamics of CD28 and 41BB signaling domains at CAR immunological ...
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AACR Annual Meeting 2023

By SITC Communications posted 04-20-2023
The Society for Immunotherapy of Cancer (SITC) is pleased to present highlights of the latest advances in immunotherapy emerging from the 2023 AACR Annual Meeting. Below is a recap of highlighted research presented from Friday, April 14 through Wednesday, April 19, 2023. Scientific Highlights A PERSONALIZED MRNA CANCER VACCINE COMBINED WITH IMMUNE CHECKPOINT INHIBITORS FOR MELANOMA CT001. A personalized cancer vaccine, mRNA-4157, combined with pembrolizumab versus pembrolizumab in patients with resected high-risk melanoma: Efficacy and safety results from the randomized, open-label Phase 2 mRNA-4157-P201/Keynote-942 trial Jeffrey ...
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