In accordance with the Institute of Medicine’s Standards for Developing Trustworthy Clinical Practice Guidelines (CPGs), SITC CPGs undergo periodic evaluation to assess if new evidence necessitates modifications to recommendations, treatment algorithms, or other guideline content. This is done through our “SITC Living Guidelines” rapid update protocols designed to ensure SITC’s CPGs are up-to-date with cutting-edge thinking and incorporate the leading expert guidance in cancer immunotherapy care – a vital service to treating clinicians and those along the whole cancer care continuum.
Rapid Update v3.1 Summary
The information below provides an overview of update v3.1 to the "Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0" published in Journal for ImmunoTherapy of Cancer (JITC).
- The FDA granted accelerated approval to lifileucel (autologous tumor-infiltrating lymphocyte therapy) for adult patients with unresectable or metastastic melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 positive a BRAF inhibitor with or without a MEK inhibitor in February 2024. Based on this approval, the Melanoma v3.0 CPG has been updated in the following locations: "Stage IV cutaneous melanoma – Patients with CNS Disease," "Stage IV cutaneous melanoma – Available agents and indications for previously-treated disease," and "Special patient populations - Patients with non-cutaneous melanoma."
How to View the Living Guideline Rapid Update
Through the use of an innovative technology, rapid updates are swiftly integrated into our existing published guidelines in a clear and concise manner. An overlay system highlights affected content and provides new text reflecting the updated Expert Panel guidance as well as important supporting information, data, and references, as applicable. These rapid updates show the progression of the changes by using a version numbering system that accompanies each new posted update.
For More Information
• SITC Melanoma CPG – Overview of all available updates and companion guideline educational offerings for this guideline
• SITC Guidelines Program – Listing of all published guidelines in the SITC CPG catalogue and more about the SITC Living Guidelines rapid updates
• Follow us on social media – #SITCGuidelines on “X” and LinkedIn
• Questions – Contact a member of the SITC guideline development staff at scientificresources@sitcancer.org