I am a postdoc research fellow at DFCI, working in the laboratory of Dr. Frank Stephen Hodi and am also being proposed as a research fellow at Harvard Medical School. At present, I am studying mechanisms of loss of MHC Class I expression in tumors: defining roles of antigen-presentation machinery in determining the efficacy of immune checkpoint blockade. I am also exploring and characterizing the novel regulators of angiogenesis that influence response to combination immune checkpoint blockade. My previous work includes implications of single-cell transcriptomics, spatial transcriptomic gene expression analysis (slide seq) and single-cell ATAC sequencing approaches to investigate the microenvironment of diabetic skin and non-diabetic skin and understating the disease pathology and molecular pathways of diabetic wound healing. My PhD was focused on understanding stress-mediated mechanisms and microRNAs-based therapeutics to address cardiomyopathy that affect the human society My research work focused on identification and characterization of miRNAs using chicken as a cardiac developmental model system. We detected huge pool of known and putative novel miRNAs using Next Generation Sequencing. Functional annotation of target genes revealed that novel miRNAs were involved in cardiac cell growth, differentiation, cardiac action potential generation, protein phosphorylation, signal transduction and many more. From my research experience, I have gained expertise in advanced molecular biology protocols; single cell sequencing, slideseq spatial gene expression analysis and RNA in situ hybridization.